Sulforaphane, what is it ?
Sulforaphane is an isothiocyanate naturally present in cruciferous species such as broccoli. It is a metabolite obtained by enzymatic hydrolysis of glucoraphanin by myrosinase.
Numerous scientific publications demonstrate the benefits of the sulforaphane which are based on 3 mechanisms of action :
- antioxidant activity (activation of Nrf2 expression)
- anti-inflammatory activity (NF-KB inhibition and Nrf2 expression)
- cellular protection
Unfortunately, eating broccoli doesn’t provide the benefits of sulforaphane! It varies according to the broccoli quality, the cooking methods or the hydrolysis capacity of our intestinal flora.
Mechanism of action of sulforaphane
SULFODYNE® the only active and stable form on the market !
SULFODYNE® 5% of active and stabilised sulforaphane
No active sulforaphane exists in the market but only its precursor, the glucoraphanin, which is offered with or without the myrosinase enzyme.
Intrigued by this active and with the desire to offer useful and effective ingredients to everyone, at Ingood by Olga, we undertook the challenge to develop an active ingredient directly titrated in active and stable sulforaphane.
First, it was necessary to find the good cruciferous source and solve the main issue : the instability of the active form.
Driven by perseverance and guided by our purpose : to offer the best of our materials and after 20 years of research, we have launched Sulfodyne®, titrated to contain 5% of sulforaphane, directly bioavailable.
Need a technical sheet ? A concept sheet ? Ask us 🙂
Sulfodyne® is :
Protected by 2 international patents
From European non GMO broccoli seeds
Made in France
Sulforaphane is 7 times more bioavailable with Sulfodyne® than in a glucoraphanin extract.
How to use Sulfodyne® in your food supplements?
- 4 health benefits :
detox, immunity, women’s health, joint health
- Recommended dosage :
100 à 400mg/day/ according to the health benefit (5 to 20mg of stabilised sulforaphane)
- 3 galenic forms :
Dry galenic forms (capsules, tablets, powder for green boosting shots)
Sulfodyne is our super powerful ingredient ! By sulforaphane's mechanisms of actions, it plays a part in 4 health benefits : detox, immunity, women's health and joint health.
To fight against xenobiotics (toxics substances foreign to the human body), defense mechanisms are naturally activated but our body can’t eliminate everything.
Mechanism of action
Sulfodyne® can help to eliminate xenobiotics from the human body thanks its antioxidant properties :
- Inhibition of the expression of phase I enzymes I responsible for activating toxic substances
- Induction of expression of phase II enzymes involved in the detox process and removal of toxic substances
- Elimination of toxic substances via urinary or biliary routes.
How to target detox with SULFODYNE® ?
- Women : beauty nutricosmetics (skin, hair, nail care)
- Athletes : detox properties, toxin elimination
- Adults and seniors : cellular protection and prevention of cellular ageing
Immunity refers to our body’s ability to defend itself against infectious agents such as bacteria, viruses, parasites and others. This defense mechanism is expressed through the immune response. Our body has two types of responses : the innate immune system and the adaptive immune system.
Mechanism of action
Sulfodyne® can play a part in immune responses, whether adaptive or innate :
- NK lymphocytes activity improvement
- Macrophages phagocytosis improvement
- Immune response (production of B lymphocytes) stimulation
- T lymphocytes modification
How to target immunity with SULFODYNE® ?
- Helicobacter pylori
- Allergies and asthma
- Flu virus, influenza
Often ignored for a long time, the women’s health segment has only been focused on the effects of menopause. Now, the market is exploring a number of symptoms, life-time diseases such as endometriosis, the premenstrual syndrome or the perinatal period. Some of these conditions are linked by an uncontrolled inflammation process.
Mechanism of action
Thanks in particular to the activation of Nrf2 expression, sulforaphane may reduce oxidative stress and/or chronic inflammation and have beneficial effects on some process or symptoms like
- Pre-menstrual & menstrual syndromes
- Endometriosis lesion volume
- Polycystic syndrome
- Menopause syndrome
How to target women health with SULFODYNE® ?
- Younger women and women :Menstrual comfort, PMS
- Older women : Menopause
Joints are complex structures composed of bones, muscles, ligaments, tendons and other tissues, often causing variable degrees of pain, accompanied by stiffness, swelling and loss of joint function often cause by chronic and ageing inflammation.
Mechanism of action
SULFODYNE® can play a part on the reduction of inflammation, cartilage and bone damage and joint pain
- Activation of the leukocytes present in the joints
- T lymphocytes, TNF-alpha, PGE2 prostaglandin and nitric oxide production inhibition
- Inflammation markers inhibition
How to target joints with SULFODYNE® ?
- 3 joint pains : osteoarthritis, rheumatoid arthritis and gout
- Adults, Athletes, Seniors and Overweighted
Sulforaphane has an antioxidant action on the human body. In addition, it can help to remove the xenobiotics from the body by inhibiting the phase I enzymes responsible for the activation of some toxic substances. It also induces the expression of the phase II enzymes involved in the detoxification process and in the removal of toxic substances.
- Boddupalli et al., 2012 : “Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins A, C, and E” Review Lien
- Houghton et al., 2016 : « Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician’s Expectation Be Matched by the Reality?” Lien
- Kubo et al., 2017 : “Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress” in vitro Lien
- Alrawaiq et al., 2023 : “ Effect of Administration of an Equal Dose of Selected Dietary Chemicals on Nrf2 Nuclear Translocation in the Mouse Liver” in vivo Lien
Sulforaphane plays a part in innate and adaptive immunity. It improves the natural mechanism of defenses by stimulating NK cells and the macrophages phagocytosis involved in the innate immunity. It stimulates the adaptive immunity response by improving circulation and antibody production and modifying the autoimmune response via T cells.
- Thejass & Kuttan, 2007 : “Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea)” in vivo Lien
- Suganuma et al., 2011 : “Stimulation of phagocytosis by sulforaphane” in vitro Lien
- Kesic et al., 2011 : “Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells” in vitro Lien
- Qu et al., 2015: “Sulforaphane epigenetically regulates innate immune responses of porcine monocyte-derived dendritic cells induced with lipopolysaccharide” in vitro Lien
- Müller et al., 2016 : “Effect of Broccoli Sprouts and Live Attenuated Influenza Virus on Peripheral Blood Natural Killer Cells: A Randomized, Double-Blind Study” clinical studies Lien
- Mahn et al., 2021 : « Potential of Sulforaphane as a Natural Immune System Enhancer » Review Lien
- Kouno et al., 2023 : « Effects of sulforaphane glucosinolates from broccoli seed extract on the immune system of healthy Japanese adults » Clinical study Lien
Sulforaphane inhibits markers of inflammation and reduces cartilage degradation in models of osteoarthritis, gout and rheumatoid arthritis. These actions of sulforaphane are mediated by its effect on the activation and migration of leukocytes in the joints, on IL-17, TNF-alpha, prostaglandins PGE2 and the production of nitric oxide.
- Kong et al., 2010 : “Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate”Lien (in vivo)
- Fragoulis et al., 2012 : “Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes”Lien (in vitro)
- Davidson et al., 2017 : “Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint”Lien (in vivo)
- Rodrigues et al., 2018 : “Sulforaphane Modulates Joint Inflammation in a Murine Model of Complete Freund’s Adjuvant-Induced Mono-Arthritis” Lien (in vivo)
- Yang et al., 2018 : “Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation” Lien (in vivo)
- Moon et al., 2021 : “The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory cytokines”Lien (in vitro)
Sulforaphane exerts anti-inflammatory activity in inflammatory diseases such as endometriosis (EM). In an animal model of endometriosis, sulforaphane dose dependently reduces endometriotic lesions and adhesions. Sulforaphane alleviated pain of sciatic endometriosis as evidenced by the increase in paw withdrawal threshold and paw withdrawal latency and also inhibited ectopic endometrial tissue growth. Sulforaphane is thought to act on the PI3K-Akt pathway, a cell signaling pathway which plays a major role in cell growth and proliferation.