SULFODYNE®

The only stabilised and active form of sulforaphane on the nutraceutical market.

Sulforaphane, what is it ?

Sulforaphane is an isothiocyanate naturally present in cruciferous species such as broccoli. It is a metabolite obtained by enzymatic hydrolysis of glucoraphanin by myrosinase.

Numerous scientific publications have demonstrated the benefits of the sulforaphane which are based on 3 main mechanisms of action :

  • antioxidant activity (activation of Nrf2 expression)
  • anti-inflammatory activity (NF-κB inhibition and activation of Nrf2 expression)
  • cellular protection (epigenetic activity)

Unfortunately, eating broccoli doesn’t provide the benefits of sulforaphane! It depends on the broccoli quality, the cooking methods or the hydrolysis capacity of our intestinal flora.

Mechanisms of action of sulforaphane

Antioxidant activity

Sulforaphane is a strong indirect antioxidant. It doesn’t directly scavenge free radicals and other reactive oxygen species (ROS). Sulforaphane is a booster of cellular antioxydant activity mainly thanks to the activation of Nrf2 expression.

Anti-inflammatory activity

Sulforaphane reduces inflammation by inducing NF-κB inhibition and Nrf2 expression. A wide range of genes are therefore involved in various inflammatory and immune responses, stimulating cellular defence mechanisms and the detoxification process.

Cellular protection

Sulforaphane has an epigenetic activity that impacts DNA methylation and histone acetylation. Some genes can be regulated by sulforaphane to induce cellular protection.

SULFODYNE® the only active and stable form of sulforaphane on the market !

SULFODYNE® 5% of active and stabilised sulforaphane

No active sulforaphane exists in the market but only its precursor, the glucoraphanin, which is offered with or without the myrosinase enzyme.

Intrigued by this active and with the desire to offer useful and effective ingredients to everyone, at Ingood by Olga, we set ourselves the challenge of developing an ingredient directly titrated in active and stable sulforaphane, an active molecule with many proven health benefits.

First, it was necessary to find the good cruciferous source and solve the main issue : the instability of the active form.

Driven by perseverance and guided by our purpose: to offer the best of our materials in respect of our ecosystems and with boldness, and after 20 years of research, we have drawn the best in broccoli. We have succeeded in stabilizing natural sulforaphane from European broccoli seeds through an innovative and patented encapsulation process. And thus, we have launched Sulfodyne®, titrated to contain 5% of sulforaphane, directly bioavailable.

Protected by 2 international patents, Sulfodyne® is the solution for a bioavailability 7 times  higher than other broccoli extract providing glucoraphanin.

Need a technical sheet ? A concept sheet ? Ask us 🙂

Sulfodyne® is :

Protected by 2 international patents

From European non GMO broccoli seeds and made in France

Sulforaphane is 7 times more bioavailable with Sulfodyne® than other broccoli extract providing glucoraphanin.

How to use Sulfodyne® in your food supplements?

  •  Health benefits:
    detox, immunity, women’s health, joints and glucose regulation
  • Recommended dosage:
    100 à 400mg/day/ according to the health benefit (5 to 20mg of stabilised sulforaphane)
  • 3 galenic forms:
    Dry galenic forms (capsules, tablets, powder for water mixing)

Health benefits

Sulfodyne is our super powerful ingredient ! By sulforaphane's mechanisms of actions, it plays a part in 5 health benefits : detox, immunity, women's health, joints and glucose regulation.

Detox

The body naturally activates its own defence mechanisms against foreign substances that are toxic to the body, called «xenobiotics» but can only partially neutralise and eliminate them.

Mechanisms of action

Sulfodyne® can help to eliminate xenobiotics from the body thanks its strong antioxidant properties:

Inhibition of the phase I enzymes expression and activation of the phase II enzymes expression involved in the detoxification process
Activation of the antioxidant enzymes expression involved in the involved in the reduction of the oxidative stress

It therefore boosts the detoxification process:
Cellular antioxydant defences increase
Removal of toxins enhancement
Oxidative stressors reduction

How to target detox with SULFODYNE® ? 

Women : beauty nutricosmetics
Athletes : detox purposes, toxins elimination
Adults and seniors : cellular protection and prevention of cellular ageing

More information
Green smoothie sulforaphane broccoli

Immunity

Immunity refers to our body’s ability to defend itself against infectious agents such as bacteria, viruses, parasites and others. This defense mechanism is expressed through the immune response. Our body has two types of responses: the innate immune system and the adaptive immune system.

Mechanisms of action

SULFODYNE® can play a role in both the preventive and acute phases by enhancing the body’s natural defence mechanisms:

Stimulation of the humoral response: antibody production enhancement
Stimulation of the innate immune system: increase in phagocytic activity and activity of natural killer cells
Antiviral activity: reduced replication and spread of the virus, virus inhibition in both prevention and treatment

How to target immunity with SULFODYNE® ? 

Immunity booster (both in preventive and acute phases)
Virus (Flu virus – Influenza – Covid-19)

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Green capsules sulforaphane detox women health immunity joints broccoli

Women’s health

Woman’s health is very large and encompasses a number of symptoms, time of life or diseases that have long been ignored by medical research like endometriosis, pre-menstrual syndrome, the perinatal period, the menopause, etc. Many of these conditions are linked by an uncontrolled oxidative stress & inflammation process. Sulforaphane is gaining interest in the possible management of some women’s health issues like menstrual comfort, endometriosis, fertility and perimenopause period in which oxidative stress and inflammation are not controlled.

Mechanisms of action

Thanks to its activation of Nrf2 expression, SULFODYNE® may reduce oxidative stress and/or chronic inflammation and have beneficial effects on some process or symptoms like:

Pre-menstrual & menstrual syndromes
Endometriosis
Menopause syndrome

How to target women health with SULFODYNE® ? 

Menstrual comfort (PMS, endometriosis)
Menopause

More information
Healthy smoothie or juice women health broccoli sulforaphane

Joints

Joints are complex structures composed of bones, muscles, ligaments, tendons and other tissues, often causing variable degrees of pain, accompanied by stiffness, swelling and loss of joint function often cause by chronic and ageing inflammation.

Mechanisms of action

SULFODYNE® can help reduce inflammation, cartilage and bone damage, and joint pain:

Inhibition of MMPs enzymes expression involved in cartilage degradation
Inhibition of COX-2 enzymes expression involved in joint pain
Inhibition of NF-kB expression and PGE2 production, reducing inflammation

How to target joints with SULFODYNE® ? 

In case of osteoarthritis, rheumatoid arthritis and joint pain:
Adults
Athletes
Seniors
Overweights

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green capsules
sulforaphane
broccoli 
sulfodyne
Sulfodyne sufloraphane glucose regulation

Glucose regulation

Control of blood glucose is crucial to prevent and delay diabetes. Sulforaphane can active the Nrf2 expression, which activation was found to prevent development of diabetes and its complications thanks to the promotion of antioxidant pathways to mitigate oxidative stress and hyperglycemic damage.

Mechanism of action

SULFODYNE® can help in glucose management:

Insulin resistance
Glucose transport enhancement
Blood glucose levels improvement

How to target glucose regulation with SULFODYNE® ? 

Glucose management
Prediabetics

Scientific publications

Detox

Sulforaphane has an antioxidant action on the human body. In addition, it can help to remove the xenobiotics from the body by inhibiting the phase I enzymes responsible for the activation of some toxic substances. It also induces the expression of the phase II enzymes involved in the detoxification process and in the removal of toxic substances.

  • Boddupalli et al., 2012 : “Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins A, C, and E” Review Link
  • Houghton et al., 2016 : « Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician’s Expectation Be Matched by the Reality?” Link
  • Kubo et al., 2017 : “Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress” in vitro Link
  • Alrawaiq et al., 2023 : “ Effect of Administration of an Equal Dose of Selected Dietary Chemicals on Nrf2 Nuclear Translocation in the Mouse Liver” in vivo Link

Immunity

Sulforaphane plays a part in innate and adaptive immunity. It improves the natural mechanism of defenses by stimulating NK cells and the macrophages phagocytosis involved in the innate immunity. It stimulates the adaptive immunity response by improving circulation and antibody production and modifying the autoimmune response via T cells.

  • Thejass  & Kuttan, 2007 : “Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea)” in vivo Link
  • Suganuma et al., 2011 : “Stimulation of phagocytosis by sulforaphane” in vitro Link
  • Kesic et al., 2011 : “Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells” in vitro Link
  • Qu et al., 2015: “Sulforaphane epigenetically regulates innate immune responses of porcine monocyte-derived dendritic cells induced with lipopolysaccharide” in vitro Link
  • Müller et al., 2016 : “Effect of Broccoli Sprouts and Live Attenuated Influenza Virus on Peripheral Blood Natural Killer Cells: A Randomized, Double-Blind Study” clinical studies Link
  • Mahn et al., 2021 : « Potential of Sulforaphane as a Natural Immune System Enhancer » Review Link
  • Kouno et al., 2023 : « Effects of sulforaphane glucosinolates from broccoli seed extract on the immune system of healthy Japanese adults » Clinical study Link

Joints health

Sulforaphane inhibits markers of inflammation and reduces cartilage degradation in models of osteoarthritis, gout and rheumatoid arthritis. These actions of sulforaphane are mediated by its effect on the activation and migration of leukocytes in the joints, on IL-17, TNF-alpha, prostaglandins PGE2 and the production of nitric oxide.

  • Kong et al., 2010 : “Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate” Link (in vivo)
  • Fragoulis et al., 2012 : “Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes” Link (in vitro)
  • Davidson et al., 2017 : “Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint” Link  (in vivo)
  • Rodrigues et al., 2018 : “Sulforaphane Modulates Joint Inflammation in a Murine Model of Complete Freund’s Adjuvant-Induced Mono-Arthritis”Link (in vivo)
  • Yang et al., 2018 : “Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation” Lien (in vivo)
  • Moon et al., 2021 : “The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory cytokines”Lien (in vitro)

Women’s health

Sulforaphane exerts anti-inflammatory activity in inflammatory diseases such as endometriosis (EM). In an animal model of endometriosis, sulforaphane dose dependently reduces endometriotic lesions and adhesions. Sulforaphane alleviated pain of sciatic endometriosis as evidenced by the increase in paw withdrawal threshold and paw withdrawal latency and also inhibited ectopic endometrial tissue growth. Sulforaphane is thought to act on the PI3K-Akt pathway, a cell signaling pathway which plays a major role in cell growth and proliferation.

  • Zhou A et al. 2019 : “Sulforaphane Attenuates Endometriosis in Rat Models Through Inhibiting PI3K/Akt Signaling Pathway”Link (in vivo)
  • Liu et al, 2020 : “Anti-nociceptive and anti-inflammatory effects of sulforaphane on sciatic endometriosis in a rat model”Link (in vivo)
Broccoli sulforaphane sulfodyne

More information ?

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